FADS3 is a Δ14Z sphingoid base desaturase that contributes to …
网页2020年2月14日 · In summary, using a combination of metabolic profiling and GWAS, we identified FADS3 to be essential for forming Δ14Z DB containing LCBs, such as d18:2 and m18:1. Our results unravel FADS3 as a Δ14Z LCB desaturase, thereby disclosing the last missing enzyme of the SL de novo synthesis pathway.
FADS3 is a Δ14Z sphingoid base desaturase that contributes to …
网页2020年2月2日 · Here, we identified fatty acid desaturase type 3 (FADS3) as a bona fide sphingoid base desaturase introducing a DB in the Δ14Z position and therefore responsible for converting d18:1 into d18:2 and 1-deoxySA (m18:0) into 1-deoxySO (m18:1).
FADS3 protein expression summary - The Human Protein Atlas
网页FADS3 is a ceramide desaturase that introduces a cis double bond between carbon 14 and carbon 15 of the SPH-containing ceramides, producing sphinga-4,14-dienine-containing ceramides (SPD ceramides). SPD ceramides occur widely in mammalian tissues and cells.
Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads ...
网页2011年1月1日 · Fads3 was also showed to be a target gene for NK-κB, MYCN or p63 transcription factors and could consequently be involved in cell survival mechanisms. Polymorphism analysis underlined the possible implication of Fads3 in lipid homeostasis, particularly by modulating cholesterol and triglyceride plasma levels.
Integrative analysis of FADS3 as a marker for prognosis and …
网页FADS3 accelerates HNSCC cell proliferation, migration, and invasion and induces EMT. (A–F) HSC3 and HN6 cells stably expressing negative control (NC) or FADS3-specific shRNA (shFADS3#1 and shFADS3#2) were applied to measure the FADS3 functions in HNSCC cells. FADS3 mRNA expression was verified by qRT-PCR (A).
Convergent and divergent transcriptional reprogramming of …
网页2024年7月14日 · In addition, we also found genes related to lipid droplet (Plin2), lipid transport (C2cd2), and highly unsaturated fatty acid biosynthesis (Fads3) that showed a significant up-regulation in injured neurons (Fig. 3 c and Fig. 4 a). Fads3 could increase docosahexaenoic acid (DHA) level during the brain development [35].
FADS3 Gene - GeneCards | FADS3 Protein | FADS3 Antibody
网页2015年8月6日 · FADS3 is a desaturase that introduces a cis (Z) double bond between carbon 14 and carbon 15 of the sphingoid base (also known as long chain base, LCB), producing LCBs such as sphinga-4,14-dienine (SPD, d18:2(4E,14Z)) from SPH (PubMed:31862735, 31916624, 37209771).
Fads3 modulates docosahexaenoic acid in liver and brain
网页Fatty acid desaturase 3 (FADS3) is the third member of the FADS gene cluster. FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid (HUFA) biosynthesis, but FADS3 function remains elusive. We generated the first Fads3 knockout (KO) mouse with an aim to characterize its metaboli …
FADS3 fatty acid desaturase 3 [ Homo sapiens (human) ]
网页Title: FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome. Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3.
Neuronal Lipid Metabolism: Multiple Pathways Driving Functional ...
网页Fatty acids can also be modified through desaturation, a process that introduces double bonds into the fatty acid chain. Depending on the desaturase enzyme used, the position and number of double bonds differs. The most common desaturases are ∆9, ∆5 and ∆6, along with fatty acid desaturase 3 (FADS3; Nakamura and Nara, 2004). Desaturation ...