Dangers of hyperoxia | Critical Care | Full Text - BioMed Central
网页2021年12月19日 · Hyperoxia injures the lung via ROS production, causing oxidant stress with pro-inflammatory and cytotoxic effects [35, 45, 46]. Pathophysiologic consequences include arterial vasoconstriction [35, 47, 48, 49], alveolar-capillary “leak” and even fibrogenesis [50, 51].
Hyperoxemia and excess oxygen use in early acute respiratory …
网页2020年3月31日 · Hyperoxemia and the resultant tissue hyperoxia may worsen systemic organ injury in the critically ill. Arterial hyperoxemia has been associated with increased mortality in some older [ 6 , 7 , 8 ] but not more recent [ 9 , …
Hemodynamic effects of acute hyperoxia: systematic review and …
网页2018年2月25日 · Background In clinical practice, oxygen is generally administered to patients with the intention of increasing oxygen delivery. Supplemental oxygen may, however, cause arterial hyperoxia, which is associated with hemodynamic alterations. We performed a systematic review and meta-analysis of the literature to determine the effect …
Bench-to-bedside review: the effects of hyperoxia during critical ...
网页2015年12月1日 · Oxygen administration is uniformly used in emergency and intensive care medicine and has life-saving potential in critical conditions. However, excessive oxygenation also has deleterious properties in various pathophysiological processes and consequently both clinical and translational studies investigating hyperoxia during critical illness have …
Impact of hyperoxia on the gut during critical illnesses
网页2024年3月1日 · The impact of hyperoxia on the gut and GM appears to vary according to the clinical situation. While hyperbaric hyperoxia may be associated with improved anastomotic healing and a decreased risk of inflammatory bowel disease flares [86, 104], excess normobaric hyperoxia has harmful effects on the gut [6].
Emergency department hyperoxia is associated with increased …
网页2018年1月18日 · ED exposure to hyperoxia is common and associated with increased mortality in mechanically ventilated patients achieving normoxia after admission. This suggests that hyperoxia in the immediate post-intubation period could be particularly injurious, and targeting normoxia from initiation of mechanical ventilation may improve …
Arterial hyperoxia and mortality in critically ill patients: a ...
网页2014年12月23日 · Introduction The safety of arterial hyperoxia is under increasing scrutiny. We performed a systematic review of the literature to determine whether any association exists between arterial hyperoxia and mortality in critically ill patient subsets. Methods Medline, Thomson Reuters Web of Science and Scopus databases were searched from …
Hyperoxia during venoarterial ECMO: Culprit or co-variate? A …
网页2022年11月8日 · Duration and timing of hyperoxia exposure We appreciate that the use of aggregate (mean PaO 2) or instantaneous (PaO 2 peak or 24 h post-cannulation) measures is a pragmatic decision. Still, variability in the reporting of PaO 2 is ultimately undesirable. The method used to measure hyperoxia have been reported inconsistently.
Hyperoxia for accidental hypothermia and increased mortality: a …
网页2023年4月1日 · Hyperoxia was defined as a PaO2 level of 300 mmHg or higher, and 28-day mortality was compared between patients with and without hyperoxia before rewarming. Inverse probability weighting (IPW) analyses with propensity scores were performed to adjust patient demographics, comorbidities, etiology and severity of hypothermia, …
网页The hyperoxia group had significantly more serious adverse events, including ICU-acquired weakness (p = 0.06). A post hoc analy-sis based on Sepsis-3 criteria found increased Day-28 mortality in patients with hyperlactataemia > 2 mmol/L. (p = 0.054), but not with normal lactate levels [76].