Hepatic stellate cell - Wikipedia
网页Hepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes).
Ito cells are liver-resident professional APCs - Nature
网页2007年2月9日 — In a study published in Immunity, scientists show that Ito cells (also known as hepatic stellate cells) in the liver have all the necessary attributes of professional antigen-presenting...
Role of Ito cells in the liver function - PubMed
网页Ito cells (perisinusoidal fat-storing cells, stellate cells, lipocytes) of the liver are mesenchymal cells located in the space of Disse. They are the main place of vitamin A storage in characteristic lipid droplets. Moreover, they demonstrate synthetic activity of collagens and other extracellular ….
Hepatic stellate cells – from past till present: morphology, human ...
网页2021年3月26日 — Human HSCs express important levels of PDGFRβ and PDGFRα [46, 50, 81,82,83,84] and several studies revealed an increased immunoreactivity of PDGFRβ in Ito cells of cirrhotic human liver [46, 85]. Other markers expressed by HSCs are programmed death-ligand 1 (PD-L1) and alpha B-crystallin (ABCRYS) .
Ito cells are liver-resident antigen-presenting cells for activating T ...
网页Here we identified Ito cells (hepatic stellate cells, HSC), known for storage of vitamin A and participation in hepatic fibrosis, as professional liver-resident antigen-presenting cells (APC). Ito cells efficiently presented antigens to CD1-, major histocompatibility complex (MHC)-I-, and MHC-II-restricted T cells.
The stellate cell system (vitamin A-storing cell system)
网页2017年3月15日 — Hepatic (HSCs) and extrahepatic stellate cells (EHSCs) form the stellate cell (SC) system or SC family; the main storage site of vitamin A in the body is HSCs in the liver. In pathological conditions such as liver fibrosis, HSCs lose vitamin A, and synthesize a large amount of extracellular matrix (ECM) components including collagen ...
Pointing at Ito cell, from structure to function (⃛ or ... - PubMed
网页Liver / metabolism*. For more than 130 years, the hepatic stellate cells (also known as Ito cells) have been the object of numerous studies that aimed at their characterization both in normal and postlesional status, where they play a key role in fibrosis progression specific for chronic hepatic pathology. Converged stu ….
Morphological Aspects of Hepatic Fibrosis and Ito Cells (Hepatic ...
网页Ito cells play a major role in various types of liver fibrosis in humans and experimental animals through initial myofibroblastic transformation. In granulation tissue following liver cell necrosis, the transformed Ito cells are large and star-shaped, and are easily...
网页In a study published in Immunity, scientists show that Ito cells (also known as hepatic stellate cells) in the liver have all the necessary attributes of professional antigen-presenting...
Ito Cells Are Liver-Resident Antigen-Presenting Cells for …
网页Here we identified Ito cells (hepatic stellate cells, HSC), known for storage of vitamin A and participation in hepatic fibrosis, as professional liver-resident antigen-presenting cells (APC). Ito cells efficiently presented antigens to CD1-, major histocompatibility complex (MHC)-I-, and MHC-II-restricted T cells.