Liver lipid metabolism - PubMed
网页The liver plays a key role in lipid metabolism. Depending on species it is, more or less, the hub of fatty acid synthesis and lipid circulation through lipoprotein synthesis. Eventually the accumulation of lipid droplets into the hepatocytes results in hepatic steatosis, which may develop as a conse ….
The regulation of hepatic fatty acid synthesis and ... - Nature
网页2019年9月25日 · Under healthy conditions, the liver regulates lipid metabolism to meet systemic energy needs in the fed and fasted states. The processes of fatty acid uptake, fatty acid synthesis and the...
Lipid metabolism in the liver - Nature
网页2023年9月13日 · Lipid metabolism in the liver ranges from uptake of chylomicron-derived lipids and fatty acids arising from adipose tissue lipolysis, among other sources, to de novo lipogenesis,...
Lipid and Lipoprotein Metabolism in Liver Disease
网页2019年7月21日 · This chapter discusses the interplay between lipid metabolism and chronic liver diseases focusing on NAFLD, alcoholic liver disease, hepatitis C, hepatitis B, cholestatic liver disease, and cirrhosis.
Lipid droplets and liver disease: from basic biology to clinical ...
网页2017年4月21日 · Depending on the body's needs, the liver utilizes lipids to generate metabolic energy, secretes them as lipoproteins, or packages them for storage. Unbalanced lipid storage and utilization...
An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver …
网页2020年7月18日 · The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload.
The liver - PMC - National Center for Biotechnology Information
网页2017年11月6日 · The liver is composed of several cell types of different embryological origin including hepatocytes, biliary epithelial cells (cholangiocytes), stellate cells, Kupffer cells, and liver sinusoidal endothelial cells. Each of these cell types possesses unique functions that cooperatively regulate hepatic function at multiple levels.
Dietary pattern and hepatic lipid metabolism - ScienceDirect
网页2023年12月1日 · The liver is the leading site for lipid metabolism, involving not only fatty acid beta-oxidation but also de novo synthesis of endogenous triglycerides and ketogenesis. The liver maintains systemic lipid homeostasis by regulating lipid synthesis, catabolism, and transportation.
Lipid Metabolism and the Liver - SpringerLink
网页2016年6月30日 · The liver plays a major role in controlling systemic lipid metabolism by importing free FAs and manufacturing, storing, and exporting lipids. An imbalance between lipid acquisition (FA uptake and de novo lipogenesis) and removal (β-oxidation and VLDL secretion) can lead to the development of insulin resistance and its associated disorders ...
Hepatic Lipid Metabolism - SpringerLink
网页2010年1月1日 · The liver is a major regulator of lipid metabolism in the body. It plays a central role in the synthesis and degradation (oxidation) of fatty acids.