The Extracellular Matrix in Skin Inflammation and Infection
网页2021年7月6日 · Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.
Extracellular Matrix Modulation: Optimizing Skin Care and
网页The extracellular matrix (ECM), constituting over 70% of the skin, is the central hub for repair and regeneration of the skin. As such, the ECM is the area where changes related to photodamage are most evident.
Spatially resolved proteomic map shows that extracellular matrix ...
网页2022年7月11日 · In this study, a hierarchical skin proteome map is constructed using spatial quantitative proteomics combined with decellularization, laser capture microdissection, and mass spectrometry. The...
Dermal extracellular matrix molecules in skin development, …
网页2022年8月1日 · In this review, we focus on the role of ECM molecules produced by dermal fibroblasts in skin development, homeostasis and wound healing, and we also discuss how disruption of ECM homeostasis may trigger the pathogenesis of skin diseases associated with abnormal wound healing response, such as …
Metabolic regulation of dermal fibroblasts contributes to skin ...
网页2019年1月7日 · Here we show a consistent downregulation in fatty acid oxidation (FAO) and upregulation of glycolysis in fibrotic skin and in normal skin with abundant ECM. Perturbation of glycolysis and FAO...
Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin ...
网页2021年11月26日 · Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging. However, the roles of the changes in ECM characteristics and the molecules that are secreted to the extracellular space and are involved in the formation of the dermal matrix from birth to old age remain unclear.
Dermal extracellular matrix molecules in skin development
网页In this review, we describe the plasticity of dFBs during development and wound healing and how various dFB-derived ECM molecules, including collagen, proteoglycans, glycosaminoglycans, fibrillins and matricellular proteins are expressed and regulated, and in turn how these ECM molecules play a role in regulating the function of dFBs and immune ...
Alterations in extracellular matrix composition during aging and ...
网页2020年6月17日 · Human skin is composed of the cell-rich epidermis, the extracellular matrix (ECM) rich dermis, and the hypodermis. Within the dermis, a dense network of ECM proteins provides structural support to the skin and regulates a wide variety of signaling pathways which govern cell proliferation and other critical processes.
Extracellular Matrix of the Skin: 50 Years of Progress
网页1989年4月1日 · The extracellular connective tissue matrix of the skin is a complex aggregate of distinct collagenous and non-collagenous components. Optimal quantities and delicate interactions of these components are necessary to maintain normal physiologic properties of skin.
Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin …
网页2021年11月25日 · Our study is the first to use a decellularized method combined with proteomics tools to investigate the molecular differences and development characteristics of the dermal matrix during skin aging. The time-resolved ECM atlas constructed in this study identifies the ECM components with different types in tollder, teenager, adult and elderly ...
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