Thrombopoietin - Wikipedia
网页Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the …
Biology and physiology of thrombopoietin - UpToDate
网页2024年5月31日 · Thrombopoietin (TPO) is the physiologically relevant regulator of platelet production. Although the concept of a platelet growth factor analogous to erythropoietin had been proposed in the 1950s, it was not until 1994 that the existence of this hematopoietic growth factor was demonstrated and the protein purified [1-5].
The molecular mechanisms that control thrombopoiesis
网页2005年12月1日 · Thrombopoietin is the most potent single stimulus of the growth of hematopoietic progenitor cells committed to the megakaryocyte lineage. It also acts in synergy with other hematopoietic cytokines, including SCF, IL-11, and erythropoietin, to promote progenitor cell proliferation .
Thrombopoietin, the Primary Regulator of Platelet Production: …
网页2024年4月18日 · Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises.
Thrombopoietin: Trends in Endocrinology & Metabolism - Cell …
网页6 • Thrombopoietin Is a Major Regulator of Platelet Production. The sine qua non of TPO is its ability to increase platelet production in vivo. When administered to mice, dogs, nonhuman primates, and most recently patients undergoing chemotherapy for lung cancer, TPO profoundly increases platelet levels (Lok et al. 1994, Kaushansky et al ...
The thrombopoietin receptor: revisiting the master regulator of ...
网页2021年6月7日 · Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL have been well characterized, culminating in the first MPL agonists being approved for the …
The biology of thrombopoietin and thrombopoietin receptor agonists
网页Thrombopoietin (TPO) is the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production.
The structure, function, and clinical use of the thrombopoietin ...
网页2022年5月1日 · Thrombopoietin regulates platelet production through activation of the thrombopoietin receptor (TPO-R). TPO-R agonists (TPO-RAs) are available to treat thrombocytopenia in chronic immune thrombocytopenia (ITP), chronic liver disease (CLD) patients who are undergoing a procedure, severe aplastic anemia (SAA), and hepatitis C …
The molecular and cellular biology of thrombopoietin: the …
网页2002年5月21日 · The term thrombopoietin (TPO) was first coined in 1958 and used to describe the humoral substance responsible for causing the platelet count to rise in response to thrombocytopenic stimuli.
Thrombopoietin | New England Journal of Medicine
网页1998年9月10日 · Thrombopoietin is effective in accelerating platelet recovery to base-line values after conventional doses of chemotherapy for cancer and after bone marrow transplantation for breast cancer.