In A Nutshell Researchers identified CGRP-producing neurons in the thalamus that connect pain signals with emotional threat ...

Scientists have discovered a brain circuit that gives pain its emotional sting, explaining why some hurts linger as suffering ...

Pain isn't just a physical sensation—it also carries emotional weight. That distress, anguish, and anxiety can turn a ...

Sensory neurons may also use CGRP to stimulate cancer through more indirect pathways. ... Timothy C. Wang. Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis. ...

The researchers found that too much of a small protein called RAMP1 appears to amplify a nerve cell receptor's response to a neuropeptide, CGRP (calcitonin gene-related peptide) Studies have shown ...

Sensory neurons grow into injured tissues and modulate the immune system to promote healing. Login. ... (RAMP1), a component of the CGRP receptor complex, rendering the cells unresponsive to CGRP.

However, signaling mechanisms between sensory neurons and other cells in the gut aren’t as well understood. We know that nociceptors signal to neighboring immune or vascular cells by releasing ...

By uncovering this nociceptor-to-macrophage communication pathway, the study suggests that targeting CGRP/RAMP1 signaling may offer new avenues for clinical intervention.

Mice treated with RAMP1 blockers were able to clear their infections faster too. It may be possible to help the immune system clear cases of bacterial meningitis with medications that block either ...

A new study from Harvard Medical School has shown that pain neurons in mice can shield the gut from damage by stimulating nearby cells to produce protective mucus. The research is published in Cell.