编辑推荐： 该研究不仅发现肝癌细胞中SUMO化修饰促进PKM2靶向质膜以微囊泡的形式外泌，进而通过诱导单核细胞分化成为M2-like巨噬细胞促进肝癌进程，还揭示微囊泡PKM2可以作为一个潜在的肝癌临床诊断标志物和治疗靶点。

GP73介导PKM2分泌协同促进肝癌血管生成与M2型巨噬细胞极化的机制及靶向治疗策略 《Cell Death & Disease》：GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma 【字体： 大 ...

《细胞·代谢》：帮T细胞猛猛加速！最新研究发现，激活丙酮酸激酶PKM2可显著增强CD8+T细胞效应功能，助力免疫治疗 ...

Pharmacological and genetic inhibition of PKM2 or EIF2AK2 attenuates NLRP3 and AIM2 inflammasomes activation, and consequently suppresses the release of IL-1β, IL-18 and HMGB1 by macrophages.

该研究阐明了ALDH1A3通过别构激活PKM2，介导胶质母细胞瘤葡萄糖代谢重编程和乳酸堆积，进而通过XRCC1乳酰化修饰促进胶质母细胞瘤放化疗抵抗的分子 ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

In recent years, the field of cancer metabolism has found that cancer cells can manipulate the PKM2 enzyme to grow and thrive. Now a new study finds that cancers also use PKM2 to withstand ...

Similarly, PKM2 high mRNA expression (HR: 1.8, p=0.005) and the presence of undifferantited tumors (HR: 2.5, p<0.0001) were revealed as independent prognostic factors for decreased mOS. Conclusions: ...

Conclusions: These results provide evidence that the PKM2 mRNA expression could be used as prognostic/predictive marker for disease recurrence in patients with operable colon cancer. Analysis of the ...

Crippling a protein that allows cancer cells to grow when oxygen is scarce causes tumors to regress, according to a study published online on January 23 in the Journal of Experimental Medicine.