编辑推荐： 本研究针对肌萎缩侧索硬化症（ALS）中能量代谢紊乱与氧化应激的协同致病机制，揭示了关键糖酵解酶PKM2在疾病早期通过双重机制发挥神经保护作用：其酶活性促进乳酸代谢减少ROS积累，核转位后直接激活Nrf2转录增强抗氧化防御。该发现为ALS的代谢-氧化应激联合干预提供了全新靶点。

GP73介导PKM2分泌协同促进肝癌血管生成与M2型巨噬细胞极化的机制及靶向治疗策略 《Cell Death & Disease》：GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma 【字体： 大 ...

Pharmacological and genetic inhibition of PKM2 or EIF2AK2 attenuates NLRP3 and AIM2 inflammasomes activation, and consequently suppresses the release of IL-1β, IL-18 and HMGB1 by macrophages.

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

Similarly, PKM2 high mRNA expression (HR: 1.8, p=0.005) and the presence of undifferantited tumors (HR: 2.5, p<0.0001) were revealed as independent prognostic factors for decreased mOS. Conclusions: ...

Conclusions: These results provide evidence that the PKM2 mRNA expression could be used as prognostic/predictive marker for disease recurrence in patients with operable colon cancer. Analysis of the ...

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

Nanjing University team showed that PKM2, an enzyme involved in the tumor cell's reliance on aerobic glycolysis (Warburg effect), plays a critical role in promoting the release of exosomes from ...