2018 Meetings Abstracts: Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic January 8–11, 2018; San Diego, CA Proceedings: AACR Annual ...

Increased exon skipping, particularly affecting proteasome-related transcripts, was mediated by elevated serine/arginine-rich splicing factor 6 (SRSF6) levels in T-cell acute lymphoblastic leukemia.

In the U.S., incidence rates of some cancers have increased in 15- to 49-year-olds with concomitant increases in older age groups, suggesting that changes in risk factor prevalence and/or improvements ...

HBV-induced upregulation of HSPA8 promotes hepatocarcinogenesis by suppressing ferroptosis and stimulating HBV replication, identifying HSPA8 as a potential therapeutic target in liver cancer.

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Abstract. The MAPK signaling pathway is commonly upregulated in human cancers. As the primary downstream effector of the MAPK pathway, ERK is an attractive therapeutic target for the treatment of MAPK ...

Preventing the feedback induction of TREX1 downstream of tumor cell STING results in robust interferon signaling and can render cancer cells vulnerable to NK and other immune cell–mediated killing, as ...

Metastasis is initiated and sustained through therapy by cancer cells with stem-like and immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress suggests that MICs result ...

AACR Journals Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Cancer Research Communications ...

A computational approach shows cryptic peptides as an abundant class of epitopes in different tumor samples. This approach can potentially be used to elucidate complete HLA-I immunopeptidomes and aid ...

Response to CD19-directed CAR T cells in acute lymphoblastic leukemia was dependent on death receptor signaling, and exposure to ALL cells with impaired death receptor signaling caused CAR T cells to ...

Genomic biomarker profiling of circulating tumor cells enabled by the MinimuMM-seq assay could be used clinically for early diagnosis, monitoring, and management of patients with multiple myeloma with ...