The heart expresses 2 main subtypes of cAMP-dependent protein kinase (PKA; type I and II) that differ in their regulatory subunits, RIα and RIIα. Embryonic lethality of RIα knockout mice limits the ...

BACKGROUND: Achievement of guideline-recommended levels of physical activity (≥150 minutes of moderate-to-vigorous physical ...

Idiopathic hypertrophic subaortic stenosis (IHSS) is a disease characterized by marked hypertrophy of the left ventricle, involving in particular the interventricular septum and the left ventricular ...

Our vision is to innovate and incorporate promising technologies to communicate freely available, high-priority, high-quality content, which accelerates scientific progress and advances heart and ...

BACKGROUND: Septal reduction therapy (SRT) provides substantial symptomatic improvement in patients with obstructive hypertrophic cardiomyopathy (HCM). However, long-term disease course after SRT and ...

Although not explicitly stated, identification of cardiovascular disease suggests that subsequent management of the cardiovascular conditions discovered could have contributed to a decreased incidence ...

Recent advances in therapy and the promulgation of multidisciplinary pulmonary embolism teams show great promise to improve management and outcomes of acute pulmonary embolism (PE). However, the ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

Frequency: Articles are individually published online, and issues are compiled 24 times per year.

Leading coronary artery, structural heart, and vascular disease science that advances practice and improves patient outcomes ...

Circulation publishes original research manuscripts, review articles, and other invited content related to cardiovascular health and disease, including observational studies, clinical trials, ...