These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic ...

After being informed of a potential microduplication in Figure 1D, the journal contacted the authors for clarification. The ...

Huntington’s disease (HD) is an incurable inherited disorder caused by a repeated expansion of glutamines in the huntingtin gene (Htt). The mutant protein causes neuronal degeneration leading to ...

Ago2 differentially regulates oncogenic and tumor-suppressive miRNAs in cancer cells. This discrepancy suggests a secondary event regulating Ago2/miRNA action in a context-dependent manner. We show ...

This month's cover highlights the article Palmitoylated Importin α Regulates Mitotic Spindle Orientation Through Interaction with NuMA by Patrick James Sutton, Natalie Mosqueda and Christopher ...

Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

imageimageIn 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the dinoflagellate Vulcanodinium rugosum, were found in Senegal’s fishing ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

imageimageThe promyelocytic leukemia protein (PML) is essential to sustain clear cell renal cell carcinoma (ccRCC) expansion via p53 inhibition and the PML-targeting drug arsenic trioxide exerts ...

Collecting duct carcinoma (CDC) remains a lethal and aggressive form of kidney cancer with no effective treatment, primarily because of our limited understanding of its underlying molecular ...

imageimageThe systemic control of tissue fibrosis by metabolic organs remains poorly understood. This study identifies procollagen C-endopeptidase enhancer-1 (PCPE-1) as an adipokine released from ...

ATP2B1 is a known regulator of calcium (Ca 2+) cellular export and homeostasis. Diminished levels of intracellular Ca 2+ content have been suggested to impair SARS-CoV-2 replication. Here, we ...