本研究针对月经性偏头痛 (MM)的发病机制，通过野生型与Ramp1基因敲除小鼠模型，首次揭示雌激素通过RAMP1动态调控三叉神经节 (TG)中降钙素基因相关肽 (CGRP)系统的分子机制。研究发现Ramp1表达与雌激素周期呈正相关，并通过表观遗传修饰影响CGRP信号通路，为开发性别特异性偏头痛治疗方案提供新靶点。

Receptor activity modifying protein 1 (RAMP1) is an integral component of several receptors including the calcitonin gene-related peptide (CGRP) receptor. It forms a complex with the calcitonin ...

In 2018, the United States Food and Drug Administration (FDA) approved Aimovig (erenumab) for the prevention of migraine. Erenumab is the first FDA approved antibody therapeutic against a ...

为解决白癜风靶向治疗药物奇缺的临床困境，上海交通大学医学院附属第一人民医院王宏林团队和杭州市第三人民医院许爱娥团队联合攻关，首先对正常和白癜风皮肤进行单细胞联合空间转录组学测序分析，首次发现白癜风皮损中存在常规Ⅰ型树突状细胞（cDC1）-CD8+ T细胞互作，且真皮cDC1特异性高表达CGRP受体CALCRL-RAMP1，提示白癜风真皮cDC1可能接受CGRP信号调控。

Sensory bins are good for children over 18 months of age. Before they're 18 months old, sensory bins are not developmentally appropriate because the possible hazards outweigh the benefits.

Sensory systems are composed of receptors that sense the sensory stimuli, brain areas involved in sensory perception and neural pathways that connect them.

Pfizer’s Vydura has become the first oral CGRP antagonist recommended for routine use by the NHS to prevent episodic migraine attacks, after being rejected earlier this year as an acute treatment.

A new sensory-friendly swim series will kick off next month for kids and adults with sensory or adaptive needs. They will be able to take a dip in the Roosevelt Park Swim Center’s leisure pool.