本研究针对月经性偏头痛 (MM)的发病机制，通过野生型与Ramp1基因敲除小鼠模型，首次揭示雌激素通过RAMP1动态调控三叉神经节 (TG)中降钙素基因相关肽 (CGRP)系统的分子机制。研究发现Ramp1表达与雌激素周期呈正相关，并通过表观遗传修饰影响CGRP信号通路，为开发性别特异性偏头痛治疗方案提供新靶点。

使用YAP磷酸化抑制剂：PY-60；ERK磷酸化抑制剂SCH77298449；ERK激动剂：C16 - PAF；CGRP激动剂有机结合，探究RAMP1、ERK和YAP之间的相互调控关系，充分地表明 ...

这些发现表明，伤害感受器神经元及其通过CGRP-Ramp1轴向杯状细胞发出信号在肠道屏障保护中发挥着关键作用。 疼痛，是我们每个人都熟知的一种 ...

By uncovering this nociceptor-to-macrophage communication pathway, the study suggests that targeting CGRP/RAMP1 signaling may offer new avenues for clinical intervention.

To investigate whether CGRP modulated immune cell activity in injured tissues, the researchers generated mice whose immune cells lacked the receptor activity modifying protein 1 (RAMP1), a component ...

Researchers have discovered that stomach cancers make electrical connections with nearby sensory nerves and use these malignant circuits to stimulate the cancer's growth and spread.

RAMP1 is a normal, required subunit of the CGRP receptor. Russo and his colleagues found that overexpression of RAMP1 protein in nerve cells increased the sensitivity and responsiveness of CGRP ...

Researchers have discovered that stomach cancers make electrical connections with nearby sensory nerves and use these malignant circuits to stimulate the cancer's growth and spread.

However, signaling mechanisms between sensory neurons and other cells in the gut aren’t as well understood. We know that nociceptors signal to neighboring immune or vascular cells by releasing ...

However, signaling mechanisms between sensory neurons and other cells in the gut aren’t as well understood. We know that nociceptors signal to neighboring immune or vascular cells by releasing ...