M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis. Interestingly, they are characterized by distinct and opposing phenotypes.

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most ...

The infiltration of TAMs (M2-macrophages & M1-macrophages) and PD-L1 expression& CD8+T-lymphocytes were evaluated using dual-IF staining, respectively. 47 cases of pulmonary infectious diseases served ...

Background: Macrophages in tumor microenvironment have been characterized as M1- and M2-polarized subtypes. Our study sought to investigate the impacts of different macrophage on lung cancer cells and ...

Carson emphasized that other factors besides the cells’ activation state determine toxicity. "We should not ignore the M1/M2 paradigm completely, as it may still be useful, but perhaps more important ...