编辑推荐： 这篇综述系统阐述了丙酮酸激酶同工酶PKM2在脂质代谢重编程中的核心作用，揭示了其通过调控糖酵解（glycolysis）、固醇调节元件结合蛋白（SREBPs）和跨膜蛋白TMEM33等通路，影响非酒精性脂肪肝（NAFLD）、动脉粥样硬化及肿瘤等疾病的分子机制，为代谢性疾病治疗提供了潜在靶点。

Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter the function of these highly plastic cells, has been the subject of intense interest in the past few years, in ...

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

编辑推荐： 本研究针对肌萎缩侧索硬化症（ALS）中能量代谢紊乱与氧化应激的协同致病机制，揭示了关键糖酵解酶PKM2在疾病早期通过双重机制发挥神经保护作用：其酶活性促进乳酸代谢减少ROS积累，核转位后直接激活Nrf2转录增强抗氧化防御。该发现为ALS的代谢-氧化应激联合干预提供了全新靶点。

Nature Reviews Cancer - Warburg effect revisitedThe authors identified PKM2 in a proteomic screen for phosphotyrosine-binding proteins. Although four pyruvate kinase isoforms exist in mammals ...

When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly reduced.

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and limited therapeutic targets.