Figure 2. Metabolic reprogramming of M1/M2 macrophages: M1 inflammatory macrophages activate HIF1α pathway, which upregulates two key enzymes of glycolysis: 6-phosphofructose-2-kinase B (PFKFB) and ...

Intrinsic glycolytic metabolism shapes PD-L1 + macrophages with antitumourigenic properties in HCC. PKM2/HIF-1α axis, elicited by hepatoma cell-derived fibronectin 1, triggers pluripotent polarisation ...

Further, SIRT5 and SIRT6 affect inflammation occurrence and development through the PKM2 pathway, and both SIRT2 and SIRT5 modulate inflammation by inhibiting oxidative stress. In macrophages, SIRT3 ...

In brain tumours, immune cells called macrophages scavenge lipid debris from the myelin sheath of neurons. These lipid-laden macrophages cause immunosuppression, and their transfer of lipids to ...

However, how its role in the metabolism of tumor cells during melanoma development remains unclear. Here, we demonstrated that TIPE promoted glycolysis by interacting with pyruvate kinase M2 (PKM2) in ...

Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different ...

Here, we report the presence of multinucleated giant cells (MGC) – a type of macrophages – in tumors from patients with HNSCC, which are associated with a favorable prognosis in treatment-naive and ...