本研究针对月经性偏头痛(MM)的发病机制，通过野生型与Ramp1基因敲除小鼠模型，首次揭示雌激素通过RAMP1动态调控三叉神经节(TG)中降钙素基因相关肽(CGRP)系统的分子机制。研究发现Ramp1表达与雌激素周期呈正相关，并通过表观遗传修饰影响CGRP信号通路，为开发性别特异性偏头痛治疗方案提供新靶点。

这些发现表明，伤害感受器神经元及其通过CGRP-Ramp1轴向杯状细胞发出信号在肠道屏障保护中发挥着关键作用。 疼痛，是我们每个人都熟知的一种 ...

ramp1具有减轻炎症和促进损伤修复的能力，其表达的改变可调节cgrp的敏感性，而且它可与clr结合并调节clr的表达，我们的研究重点是鉴定与 hiri 相关 ...

Sensory neurons grow into injured tissues and modulate the immune system to promote healing. Login. ... (RAMP1), a component of the CGRP receptor complex, rendering the cells unresponsive to CGRP.

Sensory neurons may also use CGRP to stimulate cancer through more indirect pathways. ... Timothy C. Wang. Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis. ...

By uncovering this nociceptor-to-macrophage communication pathway, the study suggests that targeting CGRP/RAMP1 signaling may offer new avenues for clinical intervention.

However, signaling mechanisms between sensory neurons and other cells in the gut aren’t as well understood. We know that nociceptors signal to neighboring immune or vascular cells by releasing ...

The researchers found that too much of a small protein called RAMP1 appears to amplify a nerve cell receptor's response to a neuropeptide, CGRP (calcitonin gene-related peptide) Studies have shown ...

The neuropeptide "calcitonin gene-related peptide" (CGRP) is a potent vasodilator and immunomodulator, secreted by peripheral sensory neurons innervating the respiratory pathways. In a study ...

A new study from Harvard Medical School has shown that pain neurons in mice can shield the gut from damage by stimulating nearby cells to produce protective mucus. The research is published in Cell.