This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

Notably, macrophage PKM2 depletion effectively alleviated APAP- and LPS/D-GalN-induced ALI, as demonstrated by ameliorated immune cells infiltration, pro-inflammatory mediators, and hepatocellular ...

GP73介导PKM2分泌协同促进肝癌血管生成与M2型巨噬细胞极化的机制及靶向治疗策略 《Cell Death & Disease》：GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma 【字体： 大 ...

Conclusion Macrophage FSTL1 promotes the progression of liver fibrosis by inducing M1 polarisation and inflammation based on the intracellular PKM2 reprogramming function of macrophages. Data are ...

We further demonstrated that PKM2-dependent lactate accumulation promotes lactylation at histone H3 lysine 9, thus further leading to epigenetic modifications of numerous transcription factors. In ...

Epigenetic modifications have been identified as critical molecular determinants influencing macrophage plasticity and heterogeneity. Among these, histone lactylation is a recently discovered ...

The overexpression and nuclear translocation of PKM2 have been well documented in CNS disease. Moreover, nuclear PKM2 was upregulated in neutrophils and macrophages in patients with ischemic stroke ...

Here, we unveil that pyruvate kinase M2 (PKM2) moonlights as a histidine kinase in a phosphoenolpyruvate (PEP)-dependent manner to catalyze PGAM1 H11 phosphorylation, that is essential for PGAM1 ...

Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages. 本文由 景杰学术 团队报道，欢迎转发到朋友圈。

Abstract. Background: Non-alcoholic steatohepatitis (NASH) and cirrhosis are major risk factors for hepatocellular carcinoma (HCC), which affects men 2-4 times more than women. In tumors Pyruvate ...

Hi，各位亲爱滴小伙伴们，本次我们将继续更新乳酸化相关的文献。 本次分享的文献题目是：Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages，影响因子10.75分，发表在Bone Research杂志上，发表时间为2022 ...