Further, SIRT5 and SIRT6 affect inflammation occurrence and development through the PKM2 pathway, and both SIRT2 and SIRT5 modulate inflammation by inhibiting oxidative stress. In macrophages, SIRT3 ...

Figure 2. Metabolic reprogramming of M1/M2 macrophages: M1 inflammatory macrophages activate HIF1α pathway, which upregulates two key enzymes of glycolysis: 6-phosphofructose-2-kinase B (PFKFB) and ...

Here, we report the presence of multinucleated giant cells (MGC) – a type of macrophages – in tumors from patients with HNSCC, which are associated with a favorable prognosis in treatment-naive and ...

In brain tumours, immune cells called macrophages scavenge lipid debris from the myelin sheath of neurons. These lipid-laden macrophages cause immunosuppression, and their transfer of lipids to ...