This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

PKM2 promotes exosome release via phosphorylating SNAP-23. Nanjing University School of Life Sciences. Journal Nature Communications Funder National Defense Basic Scientific Research Program of China ...

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

Similarly, PKM2 high mRNA expression (HR: 1.8, p=0.005) and the presence of undifferantited tumors (HR: 2.5, p<0.0001) were revealed as independent prognostic factors for decreased mOS. Conclusions: ...

Results: PKM2 mRNA expression was significantly higher in tumor areas in comparison with normal mucosa (p=0.001) and low-grade adenomas (p=0.001) as well as in tumors with BRAF mutations ...