分泌型GP73与PKM2协同重塑肿瘤微环境（TME），通过诱导血管生成和M2型巨噬细胞极化促进肝细胞癌（HCC）进展及索拉非尼耐药。 ... 《Cell Death & Disease》：GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in ...

本研究针对肌萎缩侧索硬化症（als）中能量代谢紊乱与氧化应激的协同致病机制，揭示了关键糖酵解酶pkm2在疾病早期通过双重机制发挥神经保护作用：其酶活性促进乳酸代谢减少ros积累，核转位后直接激活nrf2转录增强抗氧化防御。该发现为als的代谢-氧化应激联合干预提供了全新靶点。

A research team in Trinity College Dublin has uncovered a critical role for a protein called 'PKM2' in the regulation of immune cell types at the heart of multiple inflammatory diseases.

This new article publication from Acta Pharmaceutica Sinica B, discusses targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

Similarly, PKM2 high mRNA expression (HR: 1.8, p=0.005) and the presence of undifferantited tumors (HR: 2.5, p<0.0001) were revealed as independent prognostic factors for decreased mOS. Conclusions: ...

PKM2 promotes exosome release via phosphorylating SNAP-23. Nanjing University School of Life Sciences. Journal Nature Communications Funder National Defense Basic Scientific Research Program of China ...

Results: PKM2 mRNA expression was significantly higher in tumor areas in comparison with normal mucosa (p=0.001) and low-grade adenomas (p=0.001) as well as in tumors with BRAF mutations ...