Suramin - Wikipedia
网页Suramin is a reversible and competitive protein tyrosine phosphatase (PTPases) inhibitor, also is the potent inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).
100 Years of Suramin - PMC - National Center for Biotechnology …
网页2020年2月21日 · Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. KEYWORDS: …
100 years since the publication of the suramin formula
网页2023年12月7日 · Suramin is a polysulfonated naphthylurea developed in the 1910s by the German Bayer company (then known as Farbenfabriken vorm. Friedr. Bayer & Co. (Bayer 2023 )) for the treatment of human African trypanosomiasis or sleeping sickness caused by the two subspecies Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense 1 (Low and Manson ...
[PDF] 100 Years of Suramin - Semantic Scholar
网页2019年12月16日 · Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism.
Suramin shows promise as COVID-19 treatment - News-Medical.net
网页2020年10月12日 · A new study published on the preprint server bioRxiv * reports the elucidation of the mechanism of inhibition of SARS-CoV-2 by a non-nucleotide inhibitor called suramin. This is the first such ...
100 Years of Suramin - PubMed
网页2020年2月21日 · Suramin is also an enigmatic molecule: What are its targets? How does it get into cells in the first place? Here, we provide an overview of the many different candidate targets of suramin and discuss its modes of action and routes of cellular uptake.
Suramin - an overview | ScienceDirect Topics
网页Suramin is an anti-protozoal used for African sleeping sickness (trypanosomiasis) and river blindness (onchocerciasis). It was developed originally in 1916, but it is now being studied for treatment of prostate cancer.
Suramin | Cancer Treatment, Antiparasitic & Neurodegenerative
网页Suramin, synthetic drug used in the treatment of sleeping sickness (African trypanosomiasis), a disease caused by an infestation of the protozoan Trypanosoma and spread by the tsetse fly. Suramin is administered by intravenous injection. It is most effective when given in the early stages of.
100 years since the publication of the suramin formula - PubMed
网页2023年12月7日 · Suramin. Suramin was the first drug developed using the approach of medicinal chemistry by the German Bayer company in the 1910s for the treatment of human African sleeping sickness caused by the two subspecies Trypanosoma brucei gambiense and Trypanosoma brucei rhodesienese. However, the drug was politicall ….
Suramin - an overview | ScienceDirect Topics
网页Suramin is a complex molecule that has been used for over 90 years to treat hemolymphatic form (stage 1 disease) of both East and West African trypanosomiasis. It is administered intravenously and binds extensively to plasma proteins. Suramin is slowly excreted in the urine and persists in the plasma for several weeks after treatment.