Physiology, Thyroid Hormone - StatPearls - NCBI Bookshelf
网页2023年6月5日 · The main hormones produced by the thyroid gland are thyroxine or tetraiodothyronine (T4) and triiodothyronine (T3). Thyrotropin-releasing hormone (TRH) from the hypothalamus, thyroid-stimulating hormone (TSH) from the anterior pituitary gland, and T4 work in synchronous harmony to maintain proper feedback mechanisms and …
Mechanisms of thyroid hormone action - PMC - National Center …
网页2012年9月4日 · Thyroid hormone interacts with a wide variety of signaling pathways, and its action is modulated based on nutritional and iodine status. A range of conditions with disordered thyroid signaling has allowed us to identify key regulatory pathways that are potential therapeutic targets.
Physiology, Thyroid Function - StatPearls - NCBI Bookshelf
网页2023年3月13日 · The thyroid is an endocrine gland. Its location is in the inferior, anterior neck, and it is responsible for the formation and secretion of thyroid hormones as well as iodine homeostasis within the human body. The thyroid produces approximately 90% inactive thyroid hormone, or thyroxine (T4), and 10% active thyroid hormone, or triiodothyronine ...
Thyroid hormone synthesis and physiology - UpToDate
网页2024年1月9日 · THYROID HORMONE BIOSYNTHESIS. There are two biologically active thyroid hormones: thyroxine (T4) and 3,5,3'-triiodothyronine (T3) (figure 1). They are composed of a phenyl ring attached via an ether linkage to a tyrosine molecule. Both have two iodine atoms on their tyrosine (inner) ring.
Metabolic Messengers: Thyroid Hormones | Nature Metabolism
网页2024年4月26日 · Thyroid hormones (THs) are key hormones that regulate development and metabolism in mammals. In man, the major target tissues for TH action are the brain, liver, muscle, heart, and adipose...
Regulation of Thyroid Function, Synthesis, and Function of Thyroid ...
网页2018年5月31日 · In this chapter various aspects will be discussed of (a) the neuroendocrine regulation of thyroid function, (b) the biosynthesis of TH (i.e., the prohormone T4), (c) the local regulation of bioactive TH in target tissues, and (d) the mechanisms by which T3 exerts its biological activities.
Molecular Mechanisms of Thyroid Hormone Synthesis and Secretion …
网页2018年1月26日 · The thyroid hormone synthetic pathway comprises the following steps: (1) thyroglobulin synthesis and secretion into the follicular lumen; (2) iodine uptake into the follicular epithelial cells; (3) iodine transport and efflux into the follicular lumen; (4) oxidation of iodine, iodination of thyroglobulin tyrosine residues, and coupling of ...
Physiology, Thyroid Hormone - PubMed
网页2023年6月5日 · The thyroid gland, anterior pituitary gland, and hypothalamus comprise a self-regulatory circuit called the hypothalamic-pituitary-thyroid axis. The main hormones produced by the thyroid gland are thyroxine or tetraiodothyronine (T4) …
The role of thyroglobulin in thyroid hormonogenesis
网页2019年3月18日 · T3 and T4 are synthesized in the thyroid gland in a process that involves the iodoglycoprotein thyroglobulin. In this Review, we consider the role of thyroglobulin in thyroid hormonogenesis...
Chapter 2 Thyroid Hormone Synthesis And Secretion
网页2015年9月2日 · In human thyroid, the H 2 O 2 production and iodination process are stimulated by the calcium-phosphatidylinositol pathway (129). The quantity of H 2 O 2 produced is important especially in stimulated thyrocytes; it is comparable to the ROS production of activated leukocytes.