Doxazosin - LiverTox - NCBI Bookshelf - National Center for ...
网页2018年1月8日 — Doxazosin is extensively metabolized by the liver and generation of a mildly toxic intermediate is a possible explanation. References on the safety and potential hepatotoxicity of doxazosin and other alpha-blockers are given in the Overview on Alpha-1 Adrenergic Receptor Antagonists.
Pharmacokinetic overview of doxazosin - PubMed
网页1987年5月29日 — Clearance of doxazosin, presumably in the liver, involves the production of mainly O-demethylated and C-hydroxylated metabolites, and is low in comparison with hepatic blood flow. Protein binding is reported to be 98.3% in humans.
网页absorption of doxazosin was virtually complete (95%). Presystemic metabolism was not extensive and oral bioavailability was about 65%. Doxazosin was subject to extensive biotransformation; the major routes of metabolism were 0-demethylation (23%) and C-hy- droxylation (l2%] (Fig. 2), with only about 5% of un-
Pharmacokinetic overview of doxazosin - American Journal of …
网页Clearance of doxazosin, presumably in the liver, involves the production of mainly O-demethylated and C-hydroxylated metabolites, and is low in comparison with hepatic blood flow. Protein binding is reported to be 98.3% in humans.
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in …
网页2021年8月21日 — Purpose: To investigate the effect of doxazosin on autophagy and the activation of hepatic stellate cells (HSCs) in vivo and in vitro and determine the underlying mechanism. Methods: In vivo, a mouse liver fibrosis model was induced by the intraperitoneal injection of carbon tetrachloride (CCl 4 ).
Elucidating a Complicated Enantioselective Metabolic Profile: A …
网页2022年3月10日 — Metabolism of doxazosin by rat and human liver microsomal enzymes. A Venn diagram (A) illustrated the comparison among the metabolites found in HLM, RLM, and rat plasma. The chiral metabolic characteristics were opposite for some metabolites (e.g., M17, M18, M21, and M25) between RLM and HLM incubation systems (B).
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in …
网页2021年8月21日 — The study confirmed that doxazosin could inhibit autophagy by activating the PI3K/Akt/mTOR signaling pathway and attenuate liver fibrosis. Keywords: doxazosin, liver fibrosis, autophagy, apoptosis, mTOR. Go to: Introduction.
Pharmacokinetic overview of doxazosin - ScienceDirect
网页1987年5月29日 — Clearance of doxazosin, presumably in the liver, involves the production of mainly O-de-methylated and C-hydroxylated metabolites, and is low in comparison with hepatic blood flow. Protein binding is reported to be 98.3% in humans.
α-1 Adrenergic receptor antagonist doxazosin reverses hepatic stellate ...
网页2022年1月1日 — It is possible that the anti-fibrotic effect of doxazosin is indirect via reducing liver inflammation. In this study, we show that doxazosin also targets aHSCs, by decreasing expression of collagen type 1 at protein and mRNA level.
Doxazosin - PubMed
网页2018年1月8日 — Doxazosin is a nonselective alpha-1 adrenergic antagonist (alpha-blocker) used in the therapy of hypertension and benign prostatic hypertrophy. Doxazosin is associated with a low rate of transient serum aminotransferase elevations, but has not been linked to instances of clinically apparent acute liver injury.