The NLRP3 Inflammasome Pathway: A Review of Mechanisms …
网页2022年6月10日 — The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β ….
The NLRP3 inflammasome: molecular activation and regulation to ...
网页2019年4月29日 — NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants,...
The NLRP3 Inflammasome Pathway: A Review of Mechanisms …
网页2022年6月10日 — The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing and release of pro-inflammatory cytokines IL-1β and IL-18.
The NLRP3 Inflammasome: An Overview of Mechanisms of …
网页2019年7月6日 — The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
An update on the regulatory mechanisms of NLRP3 inflammasome ... - Nature
网页2021年4月13日 — Caspase-8 and fas-associated protein with death domain (FADD) are upstream regulators of NF-κB signaling that activate both the transcriptional priming and PTM of NLRP3 inflammasome pathway ...
NLRP3 inflammasome: a key player in the pathogenesis of life …
网页2024年7月1日 — Inflammasome priming, which induces the NLRP3 signaling pathway, is initiated by endogenous cellular components and cytokines, including lipopolysaccharide, and elevates pro-IL-18,...
The NLRP3 inflammasome: molecular activation and regulation to ...
网页Recent studies have revealed new regulators of the NLRP3 inflammasome, including new interacting or regulatory proteins, metabolic pathways and a regulatory mitochondrial hub. In this Review, we present the molecular, cell biological and biochemical bases of NLRP3 activation and regulation and describe how this mechanistic understanding is ...
The Signaling Pathways Regulating NLRP3 Inflammasome Activation …
网页2021年5月19日 — In this review, we summarize recent advances in the major signaling pathways (including TLRs, MAPK, mTOR, autophagy, PKA, AMPK, and IFNR) that regulate NLRP3 inflammasome activation, providing a brief view of the molecular network that regulates this inflammasome as a theoretical basis for therapeutic intervention of NLRP3 dysregulation-related ...
The NLRP3 inflammasome: contributions to inflammation-related …
网页2023年6月27日 — The NLRP3 inflammasome is significantly activated in a CCL 4-induced mouse model of cirrhosis, which aggravates hepatocyte death and cirrhosis through the NLRP3/caspase-1/GSDMD classical pyroptosis pathway .
The NLRP3 inflammasome: Mechanism of action, role in …
网页2020年12月1日 — The relevance of NLRP3 inflammasome activation in human pathologies has led to pharmacologic targeting of the NLRP3 signaling pathway. Various therapeutic approaches have been attempted to reach this goal, including blockage of TLR receptors, P2X7 receptor, NF-κB, caspase-1, IL-1β and IL-18, as well as NLRP3 itself.