Regulating macrophage-MSC interaction to optimize BMP-2 …
网页2023年7月1日 — In this study, we profiled macrophage-MSC interaction at different BMP-2 doses to elucidate the mechanism of BMP-2-induced osteogenesis. Our findings may provide theoretical evidence for repairing bones with a lower BMP-2 dose in clinical practice.
BMP-2 functional polypeptides relieve osteolysis via bi ... - Nature
网页2023年2月9日 — In this study, we first synthesized a bone morphogenetic protein-2 (BMP-2) functional polypeptide (BMP2pp), and evaluated the effects of BMP2pp on macrophage polarization and impaired...
Engineering immunomodulatory and osteoinductive implant …
网页2022年1月10日 — Compared to the bare TiO 2 group, Zn 2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn...
Regulating macrophage-MSC interaction to optimize BMP-2 …
网页2023年2月11日 — Anti-inflammatory drugs (Dexamethasone, Dex) promoted osteogenesis via inhibiting M1 polarization and enhancing BMP-2-induced MSC osteo-differentiation. Thus, we suggest that the osteogenic effect of BMP-2 involves macrophage-MSC interaction that is dependent on BMP-2 dose and based …
Macrophages in immunoregulation and therapeutics
网页2023年5月22日 — Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely...
Accelerated bone defect regeneration through sequential …
网页2022年8月15日 — Experiment with a rat model for critical-sized bone defect regeneration further demonstrated that the composite BMP-2@SIS hydrogel could sequentially activate M1 and M2 macrophages and promote early-stage angiogenesis, which altogether expedited final bone defect regeneration.
BMP-2 functional polypeptides relieve osteolysis via bi-regulating …
网页2023年2月9日 — In this study, we first synthesized a bone morphogenetic protein-2 (BMP-2) functional polypeptide (BMP2pp), and evaluated the effects of BMP2pp on macrophage polarization and impaired osteogenesis caused by titanium (Ti) particles in vitro.
Regulation of macrophage polarization through surface ... - Science
网页We found that the reduced scale of honeycomb-like TiO 2 structures could significantly activate the anti-inflammatory macrophage phenotype (M2), in which the 90-nanometer sample induced the highest expression level of CD206, interleukin-4, and interleukin-10 and released the highest amount of bone morphogenetic protein-2 among other scales.
Novel Strategies for Spatiotemporal and Controlled BMP-2 …
网页Bone morphogenetic protein-2 (BMP-2) has been commercially approved by the Food and Drug Administration for use in bone defects and diseases. ... Shi Q. BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization. NPJ Regen Med. 2023; 8 (1):6. doi: 10.1038/s41536-023 ...
Modulating macrophage activities to promote endogenous bone ...
网页2021年1月1日 — We introduce the phagocytic role of macrophages in different bone healing periods (‘sweeper’) and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation, vascularisation and matrix remodelling (‘mediator’), or directly driving the osteogenic differentiation of bone progenitors and bone repair (‘instr...