The CD70-CD27 axis in oncology: the new kids on the block
网页2022年1月6日 — In this review on the CD70-CD27 axis, we focus on immunotherapeutic strategies aiming at eradicating the tumor cells by specifically targeting tumor-associated CD70 overexpression, thereby abrogating the immune suppressive effects driven by chronic stimulation of the CD70-CD27 axis.
The CD70-CD27 axis in oncology: the new kids on the block
网页2022年1月6日 — The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within the tumor and its microenvironment is associated with tumor progression and immunosuppression.
CD70 expression determines the therapeutic efficacy of
网页2020年7月14日 — High resolution targeted single-cell RNA sequencing of human peripheral blood confirms the presence of CD27 − CD70 + Treg cells. These findings have important implications for Treg-based...
New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)
网页Bound to its natural ligand CD70, CD27 signalling enhances T-cell proliferation and differentiation to effector and memory T cells and therefore has potential as an immune modulatory target in cancer treatment.
Comprehensive analysis of prognosis and immune function of CD70-CD27 …
网页2023年1月26日 — CD70 mainly regulates tumor immune escape by regulating T cell-mediated tumor killing, with Tregs possibly being its primary T cell subset. Our first pan-cancer study provides a relatively comprehensive understanding of the carcinogenic role of the CD70-CD27 signaling axis in different tumors.
CD70 defines a subset of proinflammatory and CNS-pathogenic …
网页2019年1月11日 — CD70 is the unique ligand of CD27 and is expressed on immune cells only upon activation. Therefore, engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of...
Targeting CD70 with cusatuzumab eliminates acute myeloid
网页2020年6月29日 — Blocking CD70/CD27 signaling and targeting CD70-expressing LSCs with cusatuzumab, a human αCD70 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity activity,...
Targeting the CD27-CD70 Pathway to Improve Outcomes in Both …
网页2021年9月22日 — Herein, we review the CD27-CD70 co-stimulatory pathway and its therapeutic potential in 1) combination with checkpoint inhibitor and other immune therapies and 2) its potential ability to serve as a novel approach in graft- versus -host disease (GVHD) prevention.
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer ...
网页The TNFR family includes CD27 (Tnfrsf7), for which an agonistic antibody has recently entered clinical trials. In this review, we describe how CD27 co-stimulation impacts the T-cell response, with the purpose to illuminate how CD27 agonism can be exploited in cancer immunotherapy.
New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)
网页2020年3月9日 — Bound to its natural ligand CD70, CD27 signalling enhances T-cell proliferation and differentiation to effector and memory T cells and therefore has potential as an immune modulatory target in cancer treatment.