Neutrophil transendothelial migration: updates and new …
网页2019年5月16日 · The recruitment of neutrophils into tissue, also known as the neutrophil extravasation cascade, is a multiple-step process. Floating neutrophils are first captured onto the EC surface in response to inflammatory cytokines and bacteria-derived peptides via upregulation of adhesive molecules on the endothelial luminal surface.
LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate …
网页2019年4月9日 · Following crawling along the blood vessels during inflammation, neutrophils adhere to the luminal surface of the blood vessels and subsequently undergo transendothelial migration via the ...
Neutrophil recruitment and function in health and inflammation
网页2013年2月25日 · Crawling neutrophils follow the chemokine gradient along endothelium, which guides them to the preferential sites of transmigration .
Neutrophil breaching of the blood vessel pericyte layer during ...
网页2022年11月17日 · Neutrophil diapedesis is an immediate step following infections and injury and is driven by complex interactions between leukocytes and various components of the blood vessel...
Neutrophil transendothelial migration hotspots – mechanisms …
网页2021年4月1日 · During the crawling and diapedesis stages of TEM, neutrophils extensively form protrusions as a sensing mechanism to detect chemotactic cues on the endothelium. They can even poke through cell–cell junctions into the abluminal space, most likely to screen the local environment for migration cues ( Nourshargh and Alon, 2014 ).
An Intriguing Structural Modification in Neutrophil Migration …
网页2023年11月14日 · The process of neutrophil recruitment into tissue involves rolling, adhesion, crawling, and transendothelial migration [1, 4]. However, despite extensive research into this process, there are still gaps in our understanding of how neutrophils migrate to reach their target tissues.
Reverse Migration of Neutrophils: Where, When, How, and Why?
网页2016年5月1日 · Reverse abluminal crawling (rAC): abluminal (sub-EC) crawling is commonly associated with neutrophils exhibiting numerous oscillatory movements in conjunction with the formation of multiple protrusions into the venular basement membrane and the pericyte layer. This enables neutrophils to seek essential directional cues to fully breach venular ...
The extravasation cascade revisited from a neutrophil perspective
网页2021年2月1日 · The classical extravasation cascade involves selectin-mediated rolling, selectin-mediated and chemokine-mediated integrin activation leading to arrest, spreading and crawling on the endothelial surface to find permissive spots for diapedesis, abluminal crawling and breaching of the basement membrane and …
Principles of Leukocyte Migration Strategies - Cell Press
网页2020年7月17日 · Upon crossing the basement membrane, neutrophils crawl abluminally between the basement membrane and its associated sheet of pericytes, followed by 3D migration into the collagen-rich interstitial space towards the stimulus (section on Leukocyte Migration in 3D) .
Neutrophil chemotaxis | Cell and Tissue Research - Springer
网页2018年1月19日 · Neutrophils are crawling afterwards in a Mac-1-dependent fashion along an intraluminal chemokine gradient to an optimal transmigration site to breach the venular vessel wall barriers and to follow. Once inside the tissue, neutrophils migrate in a chemotactic, necrotactic and haptotactic manner towards to the site of injury.