Oxygen-induced hypercapnia in COPD: myths and facts
网页2012年10月29日 — In patients with COPD, hypoxic pulmonary vasoconstriction is the most efficient way to alter the Va/Q ratios to improve gas exchange. This physiological mechanism is counteracted by oxygen therapy and accounts for the largest increase of oxygen-induced hypercapnia.
Oxygen and Carbon Dioxide Retention in COPD - LITFL
网页2022年1月7日 — Excessive oxygen administration can lead to hypercapnic respiratory failure in some COPD patients; COPD patients with more severe hypoxemia are at higher risk of CO2 retention from uncontrolled O2 administration
COPD Hypoxia: Symptoms, Causes, and Treatments - WebMD
网页2022年9月24日 — COPD can lead to hypoxia, which is when cells or tissues in your body don’t get as much oxygen as they need. Learn more about its symptoms, causes, and treatments.
Chronic Obstructive Pulmonary Disease Compensatory Measures
网页2023年6月26日 — Maintenance of ventilation-perfusion ratio by compensatory pulmonary vasoconstriction: In COPD, the acute change that occurs immediately secondary to hypoxia is hypoxic pulmonary vasoconstriction. Alveolar dead space in COPD leads to inefficient gas exchange and a ventilation-perfusion mismatch.
Hypoxemia in patients with COPD: cause, effects, and disease ...
网页2011年3月14日 — Hypoxemia in patients with COPD: cause, effects, and disease progression. Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability internationally. Alveolar hypoxia and consequent hypoxemia increase in prevalence as disease severity increases.
Understanding Hypoxic Drive and the Release of Hypoxic …
网页2016年6月3日 — When hypoxemia exists with chronic hypercapnia, the central response to carbon dioxide is blunted, and the primary stimulus to breathe is mediated through hypoxic stimulation of the peripheral chemoreceptors. This is known as the hypoxic drive, and it …
Understanding Hypoxic Drive and the Release of Hypoxic
网页Abstract. Understanding the hypoxic drive and release of hypoxic vasoconstriction in the chronic obstructive pulmonary disease population can be somewhat confusing and misunderstood. Furthermore, the hypoxic drive theory is one in which there really is no scientific evidence to support and yet continues to prosper in every aspect of care in ...
Hypoxic-Drive Theory Revisited - Respiratory Therapy
网页2012年12月7日 — The deliberate under-oxygenation of a patient with compensated respiratory acidosis (or a diagnosis of COPD) because of fear of hypoventilation or apnea, however, creates the greater risk of inducing prolonged tissue hypoxia.
Hypoxemia in patients with COPD: cause, effects, and disease ...
网页Uncorrected chronic hypoxemia is associated with the development of adverse sequelae of COPD, including pulmonary hypertension, secondary polycythemia, systemic inflammation, and skeletal muscle dysfunction.
The Hypoxic Drive, Supplemental Oxygen, and Hypercapnia
网页2023年4月12日 — Loss of the hypoxic drive leading to CO 2 retention is traditionally considered to be problematic with supplemental oxygen therapy, particularly in patients with chronic obstructive pulmonary disease (COPD). Does oxygen-induced hypercapnia really occur, or is it is just an urban legend?