Kidney fibrosis: from mechanisms to therapeutic medicines
网页2023年3月17日 · Kidney fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a hallmark manifestation in different progressive CKD; However, at present no antifibrotic...
An update on renal fibrosis: from mechanisms to therapeutic …
网页2023年3月31日 · The purpose of this review is to provide new insights into the mechanisms of renal fibrosis, as well as prospective therapeutic approaches targeting pathological signaling and cellular events. The important role of EVs will be emphasized regarding the mechanisms and therapy of renal fibrosis.
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
网页2021年1月2日 · Several systems, molecules, and responses involved in the pathogenesis of fibrosis in CKD—both, core or regulatory signaling pathways—will be discussed in this review, particularly inflammation, renin-angiotensin system (RAS), parathyroid hormone (PTH), FGF23/klotho, microRNAs (miRs), and the vitamin D hormonal system.
Understanding the mechanisms of kidney fibrosis - Nature
网页2015年12月30日 · Renal fibrosis is an important topic that attracts broad interest in nephrology owing to its status as a hallmark and common outcome across all kinds of progressive chronic kidney disease (CKD).
Mechanisms of kidney fibrosis and routes towards therapy
网页2023年9月28日 · In this review we summarize the key mechanisms that drive kidney fibrosis, including recent advances in understanding the mechanisms, as well as potential routes for developing novel targeted antifibrotic therapeutics.
The fibrogenic niche in kidney fibrosis: components and …
网页2022年7月4日 · Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney diseases.
Understanding the mechanisms of kidney fibrosis - PMC
网页Renal fibrosis is an important topic that attracts broad interest in nephrology owing to its status as a hallmark and common outcome across all kinds of progressive chronic kidney disease (CKD).
Mechanisms of Renal Fibrosis - PubMed
网页2018年2月10日 · CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have clarified the cellular and molecular mechanisms underlying the disease.
Mechanisms of Renal Fibrosis - Annual Reviews
网页CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have clarified the cellular and …
Kidney fibrosis: Emerging diagnostic and therapeutic strategies
网页2023年10月1日 · Kidney fibrosis is a consequence of any kind of severe or ongoing injury and a common feature of CKD. Fibrosis is an active process, directly contributing to the development and progression of CKD, which can ultimately lead to end-stage kidney disease (ESKD).