WDR5 is a conserved regulator of protein synthesis gene expression
网页2020年4月4日 · In this study, we compare the location of WDR5 on chromatin in a panel of mouse and human cells lines of diverse cancer types, and use a WIN site inhibitor to interrogate how WDR5 is tethered to chromatin in different contexts and to reveal the gene networks under the influence of WDR5.
Global identification of Arabidopsis lncRNAs reveals the regulation …
网页2018年11月29日 · MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3).
WDR5, a complexed protein - Nature Structural & Molecular …
网页To understand the mechanism by which WDR5 selectively recognizes H3K4me2, four groups undertook independent structural and functional studies of human WDR5 in complex with H3K4 peptides in...
WDR5 is a conserved regulator of protein synthesis gene expression
网页2020年4月6日 · WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the 'WIN' site) showing efficacy agains ….
Histone H3 Peptide Pull-Down Assays Using a Recombinant WDR5a.
网页For instance, WDR5a, the homolog of human WDR5 (for WD repeat domain 5), serves as a core component of the COMPASS-like histone methyltransferase complex required for H3K4 trimethylation at the...
Establishment of the Winter-Annual Growth Habit via
网页2009年6月30日 · We identified an Arabidopsis homolog of the human WDR5, namely, WDR5a, which is a conserved core component of the human H3K4 methyltransferase complexes called COMPASS-like. We found that recombinant WDR5a binds H3K4-methylated peptides and that WDR5a also directly interacts with an H3K4 methyltransferase, ARABIDOPSIS TRITHORAX1.
WD40‐REPEAT 5a represses root meristem growth by suppressing …
网页2018年1月6日 · Here, we identified Arabidopsis WD40-REPEAT 5a (WDR5a) as a novel factor that functions in root growth by modulating NO accumulation. The wdr5a-1 mutant accumulated less NO and produced longer roots than the wild type, whereas the WDR5a overexpression lines had the opposite phenotype.
The Arabidopsis DREAM complex antagonizes WDR5A to modulate ... - PNAS
网页DREAM target genes exhibit characteristic enrichment of H2A.Z and H3K4me2 modification on chromatin. We further showed that BTE1 directly interacts with WDR5A, a core component of COMPASS-like complex, repressing WDR5A chromatin binding and the elongation of transcription on DREAM target genes.
WDR5a functions in cadmium-inhibited root meristem growth by …
网页2020年10月9日 · WDR5a plays a key role in Cd-induced NO accumulation and meristem growth suppression in root. Previously, we reported that WDR5a functions in plant drought stress tolerance and root meristem growth by affecting NOS-like activity and NO accumulation in Arabidopsis (Liu et al. 2017, 2018).
Exploring the kinetics of the Win-site of WDR5 - Cell Press
网页2022年2月11日 · WD repeat protein-5 (WDR5), a well-established protein hub, plays an important role in multiple cellular pathways. It is crucial to the regulation of methylation of histone H3 Lys 4 (H3K4) by the SET1 family of proteins. There are 6 known SET1 proteins: MLL1, MLL2, MLL3, MLL4, SETd1A and SETd1B. The …