Platelet Activation: The Mechanisms and Potential Biomarkers
网页2016年6月15日 · Activated platelets can induce NET formation, form platelet-neutrophil and platelet-platelet aggregates, and be trapped by NET. This association between platelets and leukocytes leading to the release of intravascular NET provides new opportunities for the development of diagnostic assays in severe inflammatory diseases [ 10 ].
Platelet biology and functions: new concepts and clinical ... - Nature
网页2018年11月14日 · As secretory cells, activated platelets release multiple substances from different storage granules: α-granules, δ-granules, and lysosomes.
Physiology, Platelet Activation - StatPearls - NCBI Bookshelf
网页2023年5月1日 · Hemostasis occurs in two phases: platelet activation to form a static plug and stabilization of this plug through extrinsic and intrinsic coagulation pathways, known as primary and secondary hemostasis, respectively. This article reviews the physiological components of platelet activation during primary hemostasis.
Platelets and Their Role in Hemostasis and Thrombosis—From …
网页2022年10月23日 · Activated platelets release a vast array of growth and angiogenic factors, cytokines, and chemokines (Table 1). Once released, these molecules act to regulate the chemotaxis, inflammation, and vasomotor function critical for restoring the integrity of injured vascular walls, for angiogenesis, and for the growth of …
Super-resolution imaging of platelet-activation process and its ...
网页2021年5月18日 · Understanding the platelet activation molecular pathways by characterizing specific protein clusters within platelets is essential to identify the platelet activation state and improve...
A guide to molecular and functional investigations of platelets to ...
网页2022年3月3日 · Platelet-activated glycoprotein αIIbβ3 antibody (PAC-1) is a specific monoclonal antibody that recognizes an epitope present on the activated form of human αIIbβ3 and can be used to ...
Platelet Activation: The Mechanisms and Potential Biomarkers
网页Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this review, we discuss recent advances in the pathways of platelet activation and potential application of platelet activation biomarkers to diagnosis and prediction of disease states.
Platelet-Activation Mechanisms and Vascular Remodeling
网页This overview article for the Comprehensive Physiology collection is focused on detailing platelets, how platelets respond to various stimuli, how platelets interact with their external biochemical environment, and the role of platelets in …
Circulating Platelets as Mediators of Immunity, Inflammation, and ...
网页2018年1月19日 · In addition to their well-described hemostatic function, platelets are active participants in the immune response to microbial organisms and foreign substances. Although incompletely understood, the immune role of platelets is a delicate balance between its pathogenic response and its regulation of thrombotic and hemostatic functions.
Platelet Activation Mechanisms and Consequences of Immune ...
网页2021年12月1日 · The activated platelets in turn modulate the function of the innate and adaptive immune system by releasing multiple pro-inflammatory and immune mediators or through direct cellular interactions with immune cells, such as B and T cells.