HIV Antiretroviral Therapy - StatPearls - NCBI Bookshelf
网页2022年9月20日 · There are 6 classes of drugs used in antiretroviral therapy. These drugs generally fall into classes according to the phase of the HIV life cycle they inhibit. More common combinations include 2 nucleoside reverse transcriptase inhibitors (NRTIs) and 1 non-nucleoside reverse transcriptase inhibitor (NNRTI), a protease inhibitor (PI), or an ...
Key Principles of Antiretroviral Pharmacology - PubMed
网页Understanding the dosage forms, adverse effects, and drug interactions of antiretrovirals allow clinicians to choose the most appropriate regimen for their patient. New developments, such as branded generic regimens and long-acting intramuscular injections, may play a larger role in the future.
Clinical Pharmacology in HIV Therapy - PMC - National Center for ...
网页2019年3月3日 · There are five main classes of combination antiretroviral therapy drugs that target distinct steps of the HIV-1 cycle. One class contains agents that interfere with viral entry (entry inhibitors) into the cell by binding to viral envelope proteins and preventing attachment and entry into CD4 cells via two discrete phases in viral entry ...
Pharmacodynamics of Antiretroviral Agents | SpringerLink
网页2016年3月30日 · Antiretrovirals. Concentration–response. Protease inhibitors. Non-nucleoside reverse transcriptase inhibitors. 1 Overview of HIV Infection. In the early 1980s, several cases of a cellular-immune dysfunction were reported in the USA [1] and soon after, the term Acquired Immune Deficiency Syndrome (AIDS) was coined.
Update and latest advances in antiretroviral therapy
网页2022年1月1日 · In this review, we provide an overview on currently available anti-HIV drugs and the latest developments in antiretroviral therapy, focused on new antiretroviral agents acting on known and unexploited antiviral targets, prevention therapies aimed to improve available drug combinations, and research on new long-acting therapies, particularly ...
Update and latest advances in antiretroviral therapy - PubMed
网页In this review, we provide an overview on currently available anti-HIV drugs and the latest developments in antiretroviral therapy, focused on new antiretroviral agents acting on known and unexploited antiviral targets, prevention therapies aimed to improve available drug combinations, and research on new long-acting therapies, particularly ...
The Clinical Pharmacology of Antiretrovirals for HIV Prevention
网页We review key, recent clinical pharmacology studies to aid interpretation of completed pre-exposure prophylaxis (PrEP) randomized clinical trials (RCTs) using antiretroviral (ARV) drugs. The goal is to establish concentration-response between and within studies to identify effective target drug concentrations and other influential variables ...
Antiretroviral pharmacology - ScienceDirect
网页2018年5月1日 · Antiretroviral medications and their mechanisms of action. There are now >30 ARV drugs available as either single agents or combination tablets. These come from five classes of ARV, each acting at distinct sites in the HIV life cycle (Figure 1). Entry inhibitors prevent attachment of HIV to the target cell surface (CD4+ lymphocytes, various ...
(PDF) Antiretroviral Drugs for Treatment and Prevention of HIV ...
网页2020年10月27日 · Antiretroviral therapy is recommended as soon as possible for all individuals with HIV who have detectable viremia. Most patients can start with a 3-drug regimen or now a 2-drug regimen,...
Consensus recommendations for the use of novel antiretrovirals in ...
网页2024年6月10日 · Three agents have been approved by the U.S. Food and Drug Administration (FDA) since 2018, representing a significant advancement for this population: ibalizumab, fostemsavir, and lenacapavir. However, there is a paucity of recommendations endorsed by national and international guidelines describing the …