A Patient-Derived Glioblastoma Organoid Model and Biobank …
网页2019年12月26日 · A rapid and reliable method to generate patient-derived glioblastoma organoids captures the features and diversity of their respective parental tumors to allow for testing personalized therapies correlated to organoid profile and the establishment of a biobank for further basic and translational glioblastoma research.
Establishment of patient-derived organoid models of lower-grade glioma ...
网页2022年4月1日 · Results: Organoid models were created with a success rate of 91% (n = 20/22) from primary tumor samples across glioma histological subtypes and tumor grades (WHO Grades 1-4), and a success rate of 87% (13/15) for WHO Grade 1-3 tumors. Patient-derived organoids recapitulated stemness, proliferative, …
A Patient-Derived Glioblastoma Organoid Model and Biobank ... - PubMed
网页2020年1月9日 · Here, we report methods for generating and biobanking patient-derived glioblastoma organoids (GBOs) that recapitulate the histological features, cellular diversity, gene expression, and mutational profiles of their corresponding parental tumors.
Generation and biobanking of patient-derived glioblastoma ... - Nature
网页2020年11月9日 · Tumor organoids are 3D tissues generated directly from patient tumor cells that recapitulate features of their parent tumors. Recently, tumor organoids have emerged as a valuable model for many...
A multidimensional atlas of human glioblastoma-like organoids …
网页2024年1月26日 · Here, we use advanced human GBM-like organoid (LEGO: Laboratory Engineered Glioblastoma-like Organoid) models and provide an unprecedented comprehensive characterization of LEGO models using ...
The generation of glioma organoids and the comparison of two …
网页2024年3月8日 · We successfully established a glioma organoid model using the microtumor and Matrigel methods. Cellular heterogeneity within glioma organoids makes it possible to simultaneously culture functionally and phenotypically diverse stem cells with glioma cell populations.
Organoid models of glioblastoma: advances, applications and …
网页2020年8月1日 · GBM organoids (GBOs) are promising high-fidelity models that can be applied to model the disease, develop drugs, establish a living biobank, mimic therapeutic responses and explore personalized therapy. However, GBO models face some challenges, including deficient immune responses, absent vascular system and controversial reliability.
Modeling Patient-Derived Glioblastoma with Cerebral Organoids
网页2019年3月19日 · Our cerebral organoid glioma (GLICO) model shows that GSCs home toward the human cerebral organoid and deeply invade and proliferate within the host tissue, forming tumors that closely phenocopy patient GBMs.
Trends and challenges in modeling glioma using 3D human …
网页2020年12月1日 · Brain organoids’ suitability in modeling glioma has started to emerge, offering another usefulness of brain organoids in disease modeling.
Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells
网页2020年4月15日 · Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells. Roberta Azzarelli * Unit of Cell and Developmental Biology, Department of Biology, University of Pisa, Pisa, Italy. Glioblastoma represents an aggressive form of brain cancer characterized by poor prognosis and a 5-year survival rate of only 3–7%.