Platelets: a critical link between inflammation and …
网页2012年3月1日 · These mediators engage with receptors on platelets to elicit an activation response that is characterized by the degranulation of dense granules and/or α-granules, release of platelet products, and mobilization and activation of platelet adhesion molecules.
Platelets and Their Role in Hemostasis and Thrombosis—From …
网页2022年10月23日 · Platelet degranulation is a complex process that involves granules’ merging and fusion in the platelet center, as well as their fusion with the open canalicular system and with the plasma membrane.
A guide to molecular and functional investigations of platelets to ...
网页2022年3月3日 · The presence of CD62P (P-selectin) and receptor TREML1 on the platelet surface, usually found in α-granules of platelets, is a marker of activation-coupled degranulation.
Circulating Platelets as Mediators of Immunity, Inflammation, and ...
网页2018年1月19日 · Platelet-mediated interactions with vascular or circulating cells. Platelets interact with endothelial and immune cells in the circulation, orchestrating a response to microbes, inflammatory stimuli, and vessel damage.
Mechanism Action of Platelets and Crucial Blood Coagulation …
网页2017年10月1日 · Platelets, which circulate within the blood, are the essential mediators that trigger the mechanical pathway of the coagulation cascade upon encountering any damage to the blood vessels. Platelets encourage primary hemostasis via three major processes: activation, adhesion and aggregation.
Frontiers | The Era of Thromboinflammation: Platelets Are …
网页2019年9月12日 · Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums.
Understanding and Evaluating Platelet Function | Hematology, …
网页2010年12月4日 · Inappropriate platelet activation, whether initiated by plaque rupture or less dramatic vascular events, leads to arterial occlusion, ischemia, and tissue injury. In the setting of the hemostatic response to injury, platelets are activated by collagen and thrombin.
Platelets: at the nexus of antimicrobial defence - Nature
网页2014年5月16日 · Key Points. Platelets have multiple direct and indirect functions that integrate innate and adaptive antimicrobial host defences. Platelets actively sense signals of tissue injury and microbial...
网页The ability of platelets to influence other cells arises not only from granules (α-granules, dense granules and lysosomes) but also pos-sibly via microvesicles, exosomes, apoptotic bodies and...
Platelet morphology - De Gruyter
网页Introduction. The examination of a peripheral blood (PB) smear should be requested in every case of unexplained thrombocytopenia or thrombocytosis.